The announcement comes two days after rival Uber Technologies said its self-driving trucks will haul cargo on Arizona highways.
Waymo had been road testing its self-driving trucks in California and Arizona over the last year, since making it public in July 2017.
“As our self-driving trucks hit the highways in the region, we will have highly-trained drivers in the cabs to monitor systems and take control if needed,” Waymo said in a blog post.